Open near infrared fluorescence imaging
The LightIR is an open fluorescence imaging device designed for preclinical fluorescence imaging or clinical research.
Vascular imaging in mouse after injection of NIR-II fluorescent nanoparticles
Key Features:
1. Near infrared fluorescence and NIR-II fluorescence
2. Preclinical studies, or clinical studies under IRB approval
3. Small or large animals
List of common fluorescent moieties used with the LightIR:
- Cy5, Cy5.5, Cy7, IRDye 700 and IRDye 800 from LiCOR, Indocyanine Green (ICG), ZW 800
- Rare earth (lanthanides), quantum dots and various fluorescent nanoparticles
- The various IVISense fluorescent agents (680, 700, 800)
- Alexa Fluor AF 680, AF 700, AF 750, AF 790
- infrared fluorescent protein: iRFP
Near infrared and NIR-II fluorescence
- Limited autofluorescence
- Great depth penetration
- Better resolution
NIR-II fluorescence (900 to 1650 nm)
- Virtually no autofluorescence
- Imaging through skull, bone, melanin (melanoma studies)
Product Specifications
Imaging modes | NIR-I or NIR-II fluorescence, brightfield, subtracted, overlay. Optional: RGB brightfield |
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Real-time processing | Background subtraction, brightfield/fluorescence overlay |
Emission spectral range | NIR-I : 650 - 900 nm, NIR-II : 900 - 1600 nm |
Fluorescent channels | 1 or 2 channels |
Available excitation wavelengths | 640 nm, 690 nm, 750 nm, 785 nm, 808 nm, 980 nm |
Emission filters | Set according to chosen excitation wavelengths |
Field of view | 7 cm x 7 cm |
Detector | CMOS (NIR-I) or Alize 1.7 InGaAs (NIR-II) |
Image size (px) | 1024 x 1024 (NIR-I) or 512 x 512 (NIR-II) |
Output format | TIFF images (16 bits) with metadata |
Spec Sheet
Applications
Publications
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer
Colloids and Surfaces B: Biointerfaces
6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green
Biomolecules
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore
Physiological reports
- Physiology
- Clinical
Gravity and lymphodynamics
Bioconjugate Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Synthesis and Preclinical Fluorescence Imaging of Dually Functionalized Antibody Conjugates Targeting Endothelin Receptor-Positive Tumors
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models
European Journal of Pharmaceutics and Biopharmaceutics
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels
European Journal of Cardio-Thoracic Surgery
- Physiology
- Clinical
Octreotide improves human lymphatic fluid transport a translational trial
ACS Publications
- Biochemistry & Nanosensors
- Pharmacology
Real-Time Imaging of Hepatic Inflammation Using Hydrogen Sulfide-Activatable Second Near-Infrared Luminescent Nanoprobes
Pharmaceutics
- Biochemistry & Nanosensors
Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles
Advanced Functional Materials
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Hesperetin Nanoparticle Targeting Neutrophils for Enhanced TBI Therapy
Chemical Communications
- Biochemistry & Nanosensors
Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging
Biomaterials Science
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting
Advanced Science
- Biochemistry & Nanosensors
- Neuroscience
- Pharmacology
Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury
bioRxiv
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
An EGF-modified PLGA-lanthanide nanoplatform for combined NIR-II cancer imaging and targeted drug delivery
American Journal of Physiology-Heart and Circulatory Physiology
- Physiology